Article
The CYP4502D6 *4 and *6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients.
European journal of drug metabolism and pharmacokinetics - 1 Jun 2016
Yalcıntepe Sinem, Ozdemır Ozturk, Sılan Coskun, Ozen Filiz, Uludag Ahmet, Candan Ferhan, Sılan Fatma
Abstract excerpt
The cytochrome P450 2D6 (CYP2D6) is a cytochrome P450 enzyme involved in the oxidative biotransformation of the xenobiotics, carcinogens and various clinically important drugs. Patients are evaluated in three sub-groups of extensive (EM), intermediate (IM) and poor metabolizer (PM) phenotypes due...
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