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Article

Epigenetic regulation contributes to urocortin-enhanced midbrain dopaminergic neuron differentiation.

Stem cells (Dayton, Ohio) - 1 May 2015

Huang Hsin-Yi, Chiu Tsung-Lang, Chang Hui-Fen, Hsu Hui-Ru, Pang Cheng-Yoong, Liew Hock-Kean, Wang Mei-Jen

Abstract excerpt

The production of midbrain dopaminergic (mDA) neurons requires precise extrinsic inductive signals and intrinsic transcriptional cascade at a specific time point in development. Urocortin (UCN) is a peptide of the corticotropin-releasing hormone family that mediates various responses to stress. UCN was first cloned from adult rat midbrain. However, the contribution of UCN to the development of mDA neurons is...

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Identifiers

PMID: 25641682
DOI: 10.1002/stem.1949

Genes

UCN
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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