HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chinese Han population.

doi:10.1016/j.humimm.2015.01.008

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Article

HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chinese Han population.

Human immunology - 1 Apr 2015

Lv Naqiang, Wang Zhiguang, Dang Aimin, Zhu Xilin, Liu Ying, Zheng Deyu, Liu Guozhang

Abstract excerpt

Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. Sequence specific primer-polymerase chain reaction was used to detect 10 alleles of the HLA-DQA1 gene and 13 alleles of the HLA-DQB1, -DRB1 gene. A significant increase in the frequencies of DRB1(∗)07 (Pc<0.01, OR=3.44, CI: 2.15-5.52) was observed...

Topics

Adult
Alleles
China
DNA Mutational Analysis
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DRB1 Chains
Humans
Male
Middle Aged
Polymorphism, Genetic
Takayasu Arteritis
Young Adult

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Identifiers

PMID: 25636572
DOI: 10.1016/j.humimm.2015.01.008

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