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Article

IGF-2R-G<sub>αq</sub>signaling and cardiac hypertrophy in the low-birth-weight lamb

29 Jan 2015

Abstract excerpt

The cardiac insulin-like growth factor 2 receptor (IGF-2R) can induce cardiomyocyte hypertrophy in a heterotrimeric G protein receptor-coupled manner involving αq (Gαq) or αs (Gαs). We have previously shown increased left ventricular weight and cardiac IGF-2 and IGF-2R gene expression in low-birth-weight (LBW) compared with average-birth-weight (ABW) lambs. Here, we have investigated the cardiac expression of...

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PMID: 25632020
DOI: 10.1152/ajpregu.00346.2014

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