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Fetal growth restriction and the programming of heart growth and cardiac insulin‐like growth factor 2 expression in the lamb

2 Aug 2011

Abstract excerpt

Reduced growth in fetal life together with accelerated growth in childhood, results in a ~50% greater risk of coronary heart disease in adult life. It is unclear why changes in patterns of body and heart growth in early life can lead to an increased risk of cardiovascular disease in adulthood. We aimed to investigate the role of the insulin-like growth factors in heart growth in the growth-restricted fetus and...

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PMID: 21807611
DOI: 10.1113/jphysiol.2011.211185

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