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Article

Modulation of flavivirus population diversity by RNA interference.

Journal of virology - 1 Apr 2015

Brackney Doug E, Schirtzinger Erin E, Harrison Thomas D, Ebel Gregory D, Hanley Kathryn A

Abstract excerpt

To test the hypothesis that RNA interference (RNAi) imposes diversifying selection on RNA virus genomes, we quantified West Nile virus (WNV) quasispecies diversity after passage in Drosophila cells in which RNAi was left intact, depleted, or stimulated against WNV. As predicted, WNV diversity was significantly lower in RNAi-depleted cells and significantly greater in RNAi-stimulated cells relative to that in...

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Source

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Identifiers

PMID: 25631077
DOI: 10.1128/JVI.02612-14
PMCID: PMC4403385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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