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Article

Nonconsensus West Nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo.

Journal of virology - 1 Dec 2011

Ebel Gregory D, Fitzpatrick Kelly A, Lim Pei-Yin, Bennett Corey J, Deardorff Eleanor R, Jerzak Greta V S, Kramer Laura D, Zhou Yangsheng, Shi Pei-Yong, Bernard Kristen A

Abstract excerpt

West Nile virus (WNV) is similar to other RNA viruses in that it forms genetically complex populations within hosts. The virus is maintained in nature in mosquitoes and birds, with each host type exerting distinct influences on virus populations. We previously observed that prolonged replication in mosquitoes led to increases in WNV genetic diversity and diminished pathogenesis in mice without remarkable changes...

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Identifiers

PMID: 21937657
DOI: 10.1128/JVI.05637-11
PMCID: PMC3209405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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