West Nile virus infection of Drosophila melanogaster induces a protective RNAi response.

doi:10.1016/j.virol.2008.04.021

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Article

West Nile virus infection of Drosophila melanogaster induces a protective RNAi response.

Virology - 20 Jul 2008

Chotkowski Heather L, Ciota Alexander T, Jia Yongqing, Puig-Basagoiti Francesc, Kramer Laura D, Shi Pei-Yong, Glaser Robert L

Abstract excerpt

To determine if West Nile virus (WNV) infection of insect cells induces a protective RNAi response, Drosophila melanogaster S2 and Aedes albopictus C6/36 cells were infected with WNV, and the production of WNV-homologous small RNAs was assayed as an indicator of RNAi induction. A distinct population of approximately 25 nt WNV-homologous small RNAs was detected in infected S2 cells but not C6/36 cells. RNAi...

Topics

Adenosine Triphosphatases
Aedes
Animals
Argonaute Proteins
Base Sequence
Cell Line
Chlorocebus aethiops
Culex
DNA Primers
Drosophila Proteins
Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genes, Insect

Mutation

Proteins

RNA Helicases

RNA Interference

RNA-Induced Silencing Complex

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Identifiers

PMID: 18501400
DOI: 10.1016/j.virol.2008.04.021
PMCID: PMC2518314

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