Article
ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.
The Journal of antimicrobial chemotherapy - 1 May 2015
Duraffour Sophie, Lorenzo María M, Zöller Gudrun, Topalis Dimitri, Grosenbach Doug, Hruby Dennis E, Andrei Graciela, Blasco Rafael, Meyer Hermann, Snoeck Robert
Abstract excerpt
OBJECTIVES: ST-246 is one of the key antivirals being developed to fight orthopoxvirus (OPV) infections. Its exact mode of action is not completely understood, but it has been reported to interfere with the wrapping of infectious virions, for which F13L (peripheral membrane protein) and B5R (type I glycoprotein) are required. Here we monitored the appearance of ST-246 resistance to identify its molecular target....
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