Article
In Vitro Selection and Characterization of Tecovirimat-resistant Mpox Virus.
The Journal of infectious diseases - 23 Sept 2026
Konishi Kei, Maeda Haruka, Shibazaki Misato, Shishido Takao, Igarashi Manabu, Hall William W, Sasaki Michihito, Orba Yasuko, Sawa Hirofumi, Sato Akihiko
Abstract excerpt
BACKGROUND: Mpox virus (MPXV) is the causative agent of mpox, a disease characterized by skin lesions, and remains a global threat since the recent 2022 outbreak. Tecovirimat is an antiviral agent that inhibits MPXV replication in vitro and in vivo by targeting the viral phospholipase VP37 protein and blocking viral envelope wrapping. Although tecovirimat has been administered to many mpox patients, the emergence...
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- Animals
- Humans
- Antiviral Agents
- Cell Line
- Chlorocebus aethiops
- Drug Resistance, Viral