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Article

Focal Necrosis and Disturbed Myelination in the White Matter of Newborn Infants: A Tale of Too Much or Too Little Oxygen

12 Jan 2015

Abstract excerpt

White matter disease in preterm infants comes along with focal destructions or with diffuse myelination disturbance. Recent experimental work with transgenic mice paves the way for a unifying molecular model for both types of brain injury, placing oxygen sensing by oligodendrocyte precursor cells (OPCs) at the center stage. Mice genetically altered to mimic high local oxygen tension in oligodendroglia lineage...

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Share to Fetal and Pediatric Neurological Disorders
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Identifiers

PMID: 25629025
DOI: 10.3389/fped.2014.00143

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