Hypoxic–ischemic injury results in acute disruption of myelin gene expression and death of oligodendroglial precursors in neonatal mice

Abstract excerpt

Studies of ischemic brain injury in neonatal rodents have focused upon the pathophysiology of neuronal damage. Much less consideration has been given to white matter injury, even though it is a major contributor to chronic neurological dysfunction in children. In the human neonate, particularly in those born prematurely, periventricular white matter is highly susceptible to hypoxic--ischemic (H--I) injury. To...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anesthesia and Neurotoxicity Research
• Share to Neonatal and fetal brain pathology
• Share to Traumatic Brain Injury and Neurovascular Disturbances