Article

Optic Atrophy 1 (OPA1) regulates mitochondrial resilience and injury in neonatal hypoxia–ischaemia

2026-05-23

Abstract excerpt

Neonatal hypoxic–ischaemic encephalopathy is a leading cause of mortality and long-term neurodevelopmental impairment, in which mitochondrial dysfunction is central to injury progression, yet the molecular mechanisms linking mitochondrial dynamics to neuropathology remain incompletely defined. We combined analysis of human developmental transcriptomic datasets with in vitro primary astrocyte models and an establi...

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Literature Corpus work: 4d1ab1c3-4b6b-5644-88c4-fa287ddc7728
DOI: 10.64898/2026.05.21.726935

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