Article
Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas.
Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2005
Chen Guoan, Bhojani Mahaveer S, Heaford Andrew C, Chang Daniel C, Laxman Bharathi, Thomas Dafydd G, Griffin Laura B, Yu James, Coppola Julia M, Giordano Thomas J, Lin Lin, Adams David, Orringer Mark B, Ross Brian D, Beer David G, Rehemtulla Alnawaz
Abstract excerpt
In an effort to identify a clinical biomarker for lung cancer, we used cDNA microarray and 2D protein analyses to demonstrate that increased Fas-associated death domain (FADD) mRNA and protein were significantly associated with poor survival. Analyses of copy number and sequence of the FADD gene in 24 independent tumors ruled out the existence of an amplified and/or mutated FADD gene in aggressive lung cancers....
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