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Article

Leucine 434 is essential for docosahexaenoic acid-induced augmentation of L-glutamate transporter current.

The Journal of biological chemistry - 1 Jan 2023

Takahashi Kanako, Chen Luying, Sayama Misa, Wu Mian, Hayashi Mariko Kato, Irie Tomohiko, Ohwada Tomohiko, Sato Kaoru

Abstract excerpt

Astrocytic excitatory amino acid transporter 2 (EAAT2) plays a major role in removing the excitatory neurotransmitter L-glutamate (L-Glu) from synaptic clefts in the forebrain to prevent excitotoxicity. Polyunsaturated fatty acids such as docosahexaenoic acid (DHA, 22:6 n-3) enhance synaptic transmission, and their target molecules include EAATs. Here, we aimed to investigate the effect of DHA on EAAT2 and...

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Identifiers

PMID: 36509140
DOI: 10.1016/j.jbc.2022.102793
PMCID: PMC9823230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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