Article
NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.
Pediatric blood & cancer - 1 Jan 2017
Zgheib Nathalie K, Akika Reem, Mahfouz Rami, Aridi Carol Al, Ghanem Khaled M, Saab Raya, Abboud Miguel R, Tarek Nidale, El Solh Hassan, Muwakkit Samar A
Abstract excerpt
BACKGROUND: Interindividual variability in thiopurine-related toxicity could not be completely explained by thiopurine S-methyltransferase (TPMT) polymorphisms, as a number of patients who are homozygous wild type or normal for TPMT still develop toxicity that necessitates 6-mercaptopurine (MP) dose reduction or protocol interruption. Recently, few studies reported on an inherited nucleoside diphosphate-linked...
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