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Article

High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status

1 Apr 2021

Abstract excerpt

Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant asthma patients cluster largely into two groups: one enriched in interleukin (IL)-4 + innate immune cells and another dominated by interferon (IFN)-γ + T cells,...

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Share to Asthma and respiratory diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33852838
DOI: 10.1016/j.celrep.2021.108974

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