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Article

The novelty-seeking phenotype modulates the long-lasting effects of adolescent MDMA exposure.

Physiology & behavior - 15 Mar 2015

Rodríguez-Arias Marta, Vaccaro Sonia, Arenas M Carmen, Aguilar María A, Miñarro José

Abstract excerpt

Exposure to drugs such as ethanol or cocaine during adolescence induces alterations in the central nervous system that are modulated by the novelty-seeking trait. Our aim was to evaluate the influence of this trait on the long-term effects of MDMA administration during adolescence on spontaneous behavior and conditioned rewarding effects in adulthood. Adolescent mice were classified as high or low novelty seekers...

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PMID: 25619952
DOI: 10.1016/j.physbeh.2015.01.023

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