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Article

Reduced Motivation in Perinatal Fluoxetine-Treated Mice: A Hypodopaminergic Phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Mar 2021

Menezes Edênia C, Shah Relish, Laughlin Lindsay, Vinod K Yaragudri, Smiley John F, Cunha Catarina, Balla Andrea, Sershen Henry, Castellanos Francisco X, Corvelo André, Teixeira Cátia M

Abstract excerpt

Early life is a sensitive period, in which enhanced neural plasticity allows the developing brain to adapt to its environment. This plasticity can also be a risk factor in which maladaptive development can lead to long-lasting behavioral deficits. Here, we test how early-life exposure to the selective-serotonin-reuptake-inhibitor (SSRI), fluoxetine, affects motivation, and dopaminergic signaling in adulthood. We...

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Animals, Newborn
Dopamine
Fluoxetine
Locomotion
Mice, 129 Strain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selective Serotonin Reuptake Inhibitors

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Identifiers

PMID: 33536200
DOI: 10.1523/JNEUROSCI.2608-20.2021
PMCID: PMC8018732

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