Article
Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.
Molecular oncology - 1 Apr 2015
Massink Maarten P G, Kooi Irsan E, van Mil Saskia E, Jordanova Ekaterina S, Ameziane Najim, Dorsman Josephine C, van Beek Daphne M, van der Voorn J Patrick, Sie Daoud, Ylstra Bauke, van Deurzen Carolien H M, Martens John W, Smid Marcel, Sieuwerts Anieta M, de Weerd Vanja, Foekens John A, van den Ouweland Ans M W, van Dyk Ewald, Nederlof Petra M, Waisfisz Quinten, Meijers-Heijboer Hanne
Abstract excerpt
INTRODUCTION: BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prove valuable in clinical testing for BRCA1-involvement in patients....
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