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Article

Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.

Respiratory research - 24 Jan 2015

Gao Peng, Gibson Peter G, Baines Katherine J, Yang Ian A, Upham John W, Reynolds Paul N, Hodge Sandra, James Alan L, Jenkins Christine, Peters Matthew J, Zhang Jie, Simpson Jodie L

Abstract excerpt

BACKGROUND: Galectin-3 (gal-3), a member of the β-galactoside-binding animal lectins, is involved in the recruitment, activation and removal of neutrophils. Neutrophilic asthma is characterized by a persistent elevation of airway neutrophils and impaired efferocytosis. We hypothesized that sputum gal-3 would be reduced in neutrophilic asthma and the expression of gal-3 would be associated with other markers of...

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Identifiers

PMID: 25616863
DOI: 10.1186/s12931-014-0163-5
PMCID: PMC4314745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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