Article
Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells.
The European respiratory journal - 1 Aug 2016
den Otter Irene, Willems Luuk N A, van Schadewijk Annemarie, van Wijngaarden Simone, Janssen Kirsten, de Jeu Ronald C, Sont Jacob K, Sterk Peter J, Hiemstra Pieter S
Abstract excerpt
Which inflammatory markers in the bronchial mucosa of asthma patients are associated with decline of lung function during 14 years of prospective follow-up?To address this question, 19 mild-to-moderate, atopic asthmatic patients underwent spirometry and bronchoscopy at baseline and after 14 years of follow-up (t=14). Baseline bronchial biopsies were analysed for reticular layer thickness, eosinophil cationic...
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