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Neutrophils impaired by anti-galectin-3 antibodies elicit inflammation of endothelial cells to aggregate the development of lupus cutaneous vasculitis.

Clinical and experimental rheumatology - 1 Sept 2024

Hu Feng-Qiu, Lu Si-Yao, Shi Zhen-Rui, Lai Yu-Xian, Ren Yan-Ling, Wu Jian, Tan Guo-Zhen, Zeng Kang, Wang Liangchun

Abstract excerpt

OBJECTIVES: To investigate whether the interplay of anti-galectin-3 antibodies (anti-Gal3 Abs) with neutrophils contributes to the development of lupus cutaneous vasculitis. METHODS: Enzyme-linked immunosorbent assay was used to determine the serum level of anti-Gal3 Abs in lupus patients. Flow cytometry, quantitative PCR and western blot were performed to investigate the expression of cell surface receptors,...

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PMID: 38757282
DOI: 10.55563/clinexprheumatol/xj2knk

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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