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Article

Transcription factors GATA-3 and RORγt are important for determining the phenotype of allergic airway inflammation in a murine model of asthma.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2013

Ano Satoshi, Morishima Yuko, Ishii Yukio, Yoh Keigyou, Yageta Yuichi, Ohtsuka Shigeo, Matsuyama Masashi, Kawaguchi Mio, Takahashi Satoru, Hizawa Nobuyuki

Abstract excerpt

In refractory asthma, neutrophils, rather than eosinophils, often predominate in the airways. Neutrophilic airway inflammation appears to be resistant to steroids and may be related to the Th17, rather than the Th2, cytokine milieu. However, the role of GATA-3 and RORγt, transcription factors for Th2 and Th17 cell differentiation, respectively, in the pathogenesis of steroid-insensitive asthma remains unclear. To...

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Identifiers

PMID: 23293351
DOI: 10.4049/jimmunol.1202386

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CXCR2
MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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