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Article

Biocontainment of genetically modified organisms by synthetic protein design.

Nature - 5 Feb 2015

Mandell Daniel J, Lajoie Marc J, Mee Michael T, Takeuchi Ryo, Kuznetsov Gleb, Norville Julie E, Gregg Christopher J, Stoddard Barry L, Church George M

Abstract excerpt

Genetically modified organisms (GMOs) are increasingly deployed at large scales and in open environments. Genetic biocontainment strategies are needed to prevent unintended proliferation of GMOs in natural ecosystems. Existing biocontainment methods are insufficient because they impose evolutiona...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25607366
DOI: 10.1038/nature14121
PMCID: PMC4422498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25607366-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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