Article
High-level microsatellite instability in appendiceal carcinomas.
The American journal of surgical pathology - 1 Aug 2013
Taggart Melissa W, Galbincea John, Mansfield Paul F, Fournier Keith F, Royal Richard E, Overman Michael J, Rashid Asif, Abraham Susan C
Abstract excerpt
High-level microsatellite instability (MSI-high) is found in approximately 15% of all colorectal adenocarcinomas (CRCs) and in at least 20% of right-sided cancers. It is most commonly due to somatic hypermethylation of the MLH1 gene promoter region, with familial cases (Lynch syndrome) representing only 2% to 3% of CRCs overall. In contrast to CRC, MSI-high in appendiceal adenocarcinomas is rare. Only 4 MSI-high...
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