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Beta-carotene affects gene expression in lungs of male and female Bcmo1 −/− mice in opposite directions

3 Sept 2010

Abstract excerpt

Molecular mechanisms triggered by high dietary beta-carotene (BC) intake in lung are largely unknown. We performed microarray gene expression analysis on lung tissue of BC supplemented beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1 (-/-)) mice, which are-like humans-able to accumulate BC. Our main observation was that the genes were regulated in an opposite direction in male and female Bcmo1 (-/-) mice by...

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PMID: 20820853
DOI: 10.1007/s00018-010-0461-0

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