Article
Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread.
The Journal of infectious diseases - 15 Jul 2015
Coscolla Mireia, Barry Pennan M, Oeltmann John E, Koshinsky Heather, Shaw Tambi, Cilnis Martin, Posey Jamie, Rose Jordan, Weber Terry, Fofanov Viacheslav Y, Gagneux Sebastien, Kato-Maeda Midori, Metcalfe John Z
Abstract excerpt
The transcontinental spread of multidrug-resistant (MDR) tuberculosis is poorly characterized in molecular epidemiologic studies. We used genomic sequencing to understand the establishment and dispersion of MDR Mycobacterium tuberculosis within a group of immigrants to the United States. We used a genomic epidemiology approach to study a genotypically matched (by spoligotype, IS6110 restriction fragment length...
Topics
- California
- Disease Outbreaks
- Genome, Bacterial
- Genotype
- Humans
- Molecular Epidemiology
- Molecular Typing
- Mycobacterium tuberculosis
- Phylogeny
- Polymorphism, Restriction Fragment Length