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Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma

18 Nov 2020

Abstract excerpt

Malignant pleural mesothelioma (MPM) is an aggressive malignancy of the pleura that is currently incurable due to the lack of an effective early diagnostic method and specific medication. The CDKN2A (p16) and NF2 genes are both frequently mutated in MPM. To understand how these mutations contribute to MPM tumor growth, we generated NF2/p16 double-knockout (DKO) cell clones using human MeT-5A and HOMC-B1...

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PMID: 33298865
DOI: 10.1038/s41420-020-00364-1

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