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Article

The discrepancy between the absence of copper deposition and the presence of neuronal damage in the brain of Atp7b(-/-) mice.

Metallomics : integrated biometal science - 1 Feb 2015

Dong Yi, Shi Sheng-Sheng, Chen Sheng, Ni Wang, Zhu Min, Wu Zhi-Ying

Abstract excerpt

Wilson's disease (WD) is caused by mutations within the copper-transporting ATPase (ATP7B), characterized by copper deposition in various organs, principally the liver and the brain. With the availability of Atp7b(-/-) mice, the valid animal model of WD, the mechanism underlying copper-induced he...

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PMID: 25594375
DOI: 10.1039/c4mt00242c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25594375-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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