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Article

Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity.

Breast cancer research : BCR - 16 Jan 2015

Sriram Roshan, Lo Vivian, Pryce Benjamin, Antonova Lilia, Mears Alan J, Daneshmand Manijeh, McKay Bruce, Conway Simon J, Muller William J, Sabourin Luc A

Abstract excerpt

INTRODUCTION: Periostin (Postn) is a secreted cell adhesion protein that activates signaling pathways to promote cancer cell survival, angiogenesis, invasion, and metastasis. Interestingly, Postn is frequently overexpressed in numerous human cancers, including breast, lung, colon, pancreatic, and ovarian cancer. METHODS: Using transgenic mice expressing the Neu oncogene in the mammary epithelium crossed into...

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Share to Cell Adhesion Molecules
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mice, Transgenic

Share to Receptor, ErbB-2

Share to Receptor, Notch1

Share to Receptors, Androgen

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Source

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Identifiers

PMID: 25592291
DOI: 10.1186/s13058-014-0513-8
PMCID: PMC4355979

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PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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