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Article

β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.

The Journal of biological chemistry - 6 Mar 2015

Wong Kenneth Kin Lam, Li Wenyang, An Yanru, Duan Yangyang, Li Zhuoheng, Kang Yibin, Yan Yan

Abstract excerpt

Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for β-Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. β-spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25589787
DOI: 10.1074/jbc.M114.629493
PMCID: PMC4358275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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