Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila.

The Journal of cell biology - 6 Sept 1999

Zarnescu D C, Thomas Claire M.

Abstract excerpt

Changes in cell shape and position drive morphogenesis in epithelia and depend on the polarized nature of its constituent cells. The spectrin-based membrane skeleton is thought to be a key player in the establishment and/or maintenance of cell shape and polarity. We report that apical beta(Heavy)-spectrin (beta(H)), a terminal web protein that is also associated with the zonula adherens, is essential for normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Cell Polarity
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Morphogenesis

Share to Oogenesis

Share to Ovarian Follicle

Share to Spectrin

Source

Open in PubMed Open full text

Identifiers

PMID: 10477760
DOI: 10.1083/jcb.146.5.1075
PMCID: PMC2169487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila.PMID 10477760Read ↗

Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye.Semantic proximity Read ↗

α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium.Semantic proximity Read ↗

βHeavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesisSemantic proximity Read ↗

β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.Semantic proximity Read ↗

Drosophila beta spectrin functions independently of alpha spectrin to polarize the Na,K ATPase in epithelial cells.Semantic proximity Read ↗

Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.Semantic proximity Read ↗

Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis.Semantic proximity Read ↗

Apical spectrin organizes cortical actin filament bundles to pattern C. elegans cuticle ridges.Semantic proximity Read ↗

Drosophila filamin is required for follicle cell motility during oogenesis.Semantic proximity Read ↗

Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis.Semantic proximity Read ↗

Alpha spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans.Semantic proximity Read ↗

SMA-1 spectrin has essential roles in epithelial cell sheet morphogenesis in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.