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Article

Somatic Mutations and Genetic Heterogeneity at the CDKN1B Locus in Small Intestinal Neuroendocrine Tumors.

Annals of surgical oncology - 1 Dec 2015

Crona Joakim, Gustavsson Tobias, Norlén Olov, Edfeldt Katarina, Åkerström Tobias, Westin Gunnar, Hellman Per, Björklund Peyman, Stålberg Peter

Abstract excerpt

BACKGROUND: Until recently, the genetic landscape of small intestinal neuroendocrine tumors (SI-NETs) was limited to recurrent copy number alterations, most commonly a loss on chromosome 18. Intertumor heterogeneity with nonconcordant genotype in paired primary and metastatic lesions also is described, further contributing to the difficulty of unraveling the genetic enigma of SI-NETs. A recent study analyzing 55...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25586243
DOI: 10.1245/s10434-014-4351-9

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