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Article

POLG1-related and other "mitochondrial Parkinsonisms": an overview.

Journal of molecular neuroscience : MN - 1 May 2011

Orsucci Daniele, Caldarazzo Ienco Elena, Mancuso Michelangelo, Siciliano Gabriele

Abstract excerpt

Mitochondrial dysfunction has been implicated in the pathogenesis of sporadic, idiopathic Parkinson disease. In some cases, mitochondrial DNA primary genetic abnormalities, or more commonly, secondary rearrangements due to polymerase gamma (POLG1) gene mutation, can directly cause parkinsonism. The case of a Parkinson disease patient with some signs or symptoms suggestive of mitochondrial disease (i.e., ptosis,...

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Source

Identifiers

PMID: 21221844
DOI: 10.1007/s12031-010-9488-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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