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Article

Spontaneous immortalization of mouse liver sinusoidal endothelial cells.

International journal of molecular medicine - 1 Mar 2015

Zhao Xiuhua, Zhao Qian, Luo Zhen, Yu Yan, Xiao Na, Sun Xuan, Cheng Lamei

Abstract excerpt

The spontaneous immortalization of cells in vitro is a rare event requiring genomic instability, such as alterations in chromosomes and mutations in genes. In the present study, we report a spontaneously immortalized liver sinusoidal endothelial cell (LSEC) line generated from mouse liver. These immortalized LSECs showed typical LSEC characteristics with the structure of transcellular fenestrations, the...

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PMID: 25585915
DOI: 10.3892/ijmm.2015.2067
PMCID: PMC4314414

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Source receipt: pubmed, retrieved 7 Sept 2026.

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