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Article

Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Gibbons John G, Branco Alan T, Godinho Susana A, Yu Shoukai, Lemos Bernardo

Abstract excerpt

Tandemly repeated ribosomal DNA (rDNA) arrays are among the most evolutionary dynamic loci of eukaryotic genomes. The loci code for essential cellular components, yet exhibit extensive copy number (CN) variation within and between species. CN might be partly determined by the requirement of dosage balance between the 5S and 45S rDNA arrays. The arrays are nonhomologous, physically unlinked in mammals, and encode...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25583482
DOI: 10.1073/pnas.1416878112
PMCID: PMC4345604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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