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Disturbed Methylation at Multiple Imprinted Loci: an Increasing Observation in Imprinting Disorders

1 Oct 2011

Abstract excerpt

The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same MLMD patterns can be observed. The cause for this ambiguous epigenotype-phenotype correlation is...

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PMID: 22126250
DOI: 10.2217/epi.11.84

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