Article
Human imprinting anomalies in fetal and childhood growth disorders: clinical implications and molecular mechanisms.
Current pharmaceutical design - 1 Jan 2014
Azzi Salah, Brioude Fréderic, Le Bouc Yves, Netchine Irène
Abstract excerpt
Genomic imprinting is among the most important epigenetic mechanisms whereby expression of a subset of genes is restricted to a single parental allele. Loss of imprinting (LOI) through hypo or hyper methylation is involved in various human syndromes. These LOI occur early during development and usually impair growth. Some imprinting syndromes are the consequences of genetic anomalies, such as uniparental disomies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.