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Article

Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model

22 Dec 2014

Abstract excerpt

The etiology of Age-related Macular Degeneration (AMD) remains elusive despite the characterization of many factors contributing to the disease in its late-stage phenotypes. AMD features an immune system in flux, as shown by changes in macrophage polarization with age, expression of cytokines and complement, microglial accumulation with age, etc. These point to an allostatic overload, possibly due to a breakdown...

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PMID: 25580276
DOI: 10.3390/jcm3041542

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