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Article

Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types.

Molecular oncology - 1 Apr 2015

Lebofsky Ronald, Decraene Charles, Bernard Virginie, Kamal Maud, Blin Anthony, Leroy Quentin, Rio Frio Thomas, Pierron Gaëlle, Callens Céline, Bieche Ivan, Saliou Adrien, Madic Jordan, Rouleau Etienne, Bidard François-Clément, Lantz Olivier, Stern Marc-Henri, Le Tourneau Christophe, Pierga Jean-Yves

Abstract excerpt

Cell-free tumor DNA (ctDNA) has the potential to enable non-invasive diagnostic tests for personalized medicine in providing similar molecular information as that derived from invasive tumor biopsies. The histology-independent phase II SHIVA trial matches patients with targeted therapeutics based on previous screening of multiple somatic mutations using metastatic biopsies. To evaluate the utility of ctDNA in...

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Identifiers

PMID: 25579085
DOI: 10.1016/j.molonc.2014.12.003
PMCID: PMC5528781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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