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Article

Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies.

Computers in biology and medicine - 1 Mar 2015

Handelman Samuel K, Aaronson Jacob M, Seweryn Michal, Voronkin Igor, Kwiek Jesse J, Sadee Wolfgang, Verducci Joseph S, Janies Daniel A

Abstract excerpt

BACKGROUND: Associations between genotype and phenotype provide insight into the evolution of pathogenesis, drug resistance, and the spread of pathogens between hosts. However, common ancestry can lead to apparent associations between biologically unrelated features. The novel method Cladograms with Path to Event (ClaPTE) detects associations between character-pairs (either a pair of mutations or a mutation...

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PMID: 25577610
DOI: 10.1016/j.compbiomed.2014.12.013
PMCID: PMC4331246

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