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Article

Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.

Journal of neuropathology and experimental neurology - 1 Feb 2015

Hosokawa Masato, Arai Tetsuaki, Masuda-Suzukake Masami, Kondo Hiromi, Matsuwaki Takashi, Nishihara Masugi, Hasegawa Masato, Akiyama Haruhiko

Abstract excerpt

Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. Thus, these mutations are strongly i...

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Source

Identifiers

PMID: 25575133
DOI: 10.1097/NEN.0000000000000158

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25575133-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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