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Reduced progranulin increases tau and α -synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

2022-12-25

Abstract excerpt

Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that reduction of progranulin (PGRN), a lysosomal protein associated with TDP-43 proteinopathy, also increases tau inclusions, causes concomitant accumulation of α -synuclein and worsens mortality and...

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Literature Corpus work: aea8ac1b-be31-51ca-9d3e-2bddd2e02857
DOI: 10.1101/2022.12.25.521308

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Reduced progranulin increases tau and <i>α</i> -synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

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