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Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells

9 Jan 2015

Abstract excerpt

To overcome drug resistance caused by apoptosis deficiency in patients with non-small cell lung carcinoma (NSCLC), there is a need to identify other means of triggering apoptosis-independent cancer cell death. We are the first to report that isogambogenic acid (iso-GNA) can induce apoptosis-independent autophagic cell death in human NSCLC cells. Several features of the iso-GNA-treated NSCLC cells indicated that...

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PMID: 25571970
DOI: 10.1038/srep07697

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