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Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells

4 Aug 2017

Abstract excerpt

Isoalantolactone has recently been revealed to induce apoptosis in several types of cancer. However, little is reported on its anti-tumor potential on human lung cancer. Our present study was designed to investigate its effects on human lung squamous carcinoma SK-MES-1 cells. We found that Isoalantolactone induced cellular and DNA morphological changes and decreased the viability of SK-MES-1 cells. It...

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PMID: 28777796
DOI: 10.1371/journal.pone.0181731

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