Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ailanthone inhibits non-small cell lung cancer cell growth through repressing DNA replication via downregulating RPA1

12 Oct 2017

Abstract excerpt

BACKGROUND: The identification of bioactive compounds from Chinese medicine plays a crucial role in the development of novel reagents against non-small lung cancer (NSCLC). METHODS: High throughput screening assay and analyses of cell growth, cell cycle, apoptosis, cDNA microarray, BrdU incorporation and gene expression were performed. RESULTS: Ailanthone (Aila) suppressed NSCLC cell growth and colony formation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cell death mechanisms and regulation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29024939
DOI: 10.1038/bjc.2017.319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ailanthone inhibits non-small cell lung cancer cell growth through repressing DNA replication via downregulating RPA1PMID 29024939Read ↗

Berberine inhibits non‐small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosisSemantic proximity Read ↗

A study on the anti-tumor effect and mechanism of arsenic trioxide on lung adenocarcinomaSemantic proximity Read ↗

Inhibitory effect of 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone against NSCLC with L858R/T790M/C797S mutant EGFR.Semantic proximity Read ↗

Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC-7901 human gastric cancer cellsSemantic proximity Read ↗

Acetyltanshinone IIA reduces the synthesis of cell cycle-related proteins by degrading p70S6K and subsequently inhibits drug-resistant lung cancer cell growth.Semantic proximity Read ↗

Berberine Inhibits FoxM1 Dependent Transcriptional Regulation of POLE2 and Interferes with the Survival of Lung AdenocarcinomaSemantic proximity Read ↗

Chemical exhaustion of RPA in cancer treatmentSemantic proximity Read ↗

In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 CellsSemantic proximity Read ↗

Inhibition of CDCP1 by 8-isopentenylnaringenin synergizes with EGFR inhibitors in lung cancer treatment.Semantic proximity Read ↗

Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cellsSemantic proximity Read ↗

The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma proteinSemantic proximity Read ↗

Raddeanin A Improves the Therapeutic Effect of Osimertinib in NSCLC by Accelerating ROS/NLRP3-mediated Pyroptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.