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Article

Improving Trichoderma reesei Cel7B thermostability by targeting the weak spots.

Journal of chemical information and modeling - 27 Oct 2014

Zhang Shujun, Wang Yefei, Song Xiangfei, Hong Jingbo, Zhang Yu, Yao Lishan

Abstract excerpt

For proteins that denature irreversibly, the denaturation is typically triggered by a partial unfolding, followed by a permanent change (e.g., aggregation). The regions that initiate the partial unfolding are named "weak spots". In this work, a molecular dynamics (MD) simulation and data analysis protocol is developed to identify the weak spots of Trichoderma reesei Cel7B, an important endoglucanase in cellulose...

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Identifiers

PMID: 25286389
DOI: 10.1021/ci500339v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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