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Chromosomal instability but lack of transformation in human myoblast preparations.

Cell transplantation - 1 Jan 2014

Bisson Aurélie, Le Corre Stéphanie, Joly-Helas Géraldine, Chambon Pascal, Demoulins Laetitia, Jean Laetitia, Adriouch Sahil, Drouot Laurent, Giverne Camille, Roussel Francis, Jacquot Serge, Doucet Christelle, Michot Francis, Lamacz Marek, Frébourg Thierry, Flaman Jean-Michel, Boyer Olivier

Abstract excerpt

Genetic alterations have recently been described as emerging during the culture of embryonic stem cells or induced pluripotent stem cells, raising concerns about their safety in future clinical use. Myoblasts are adult stem cells with important therapeutic potential that have been used in clinical trials for almost 20 years, but their genome integrity has not yet been established. Here we produced 10 human...

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PMID: 25565635
DOI: 10.3727/096368913X670192

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TERT

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