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Article

Hypothalamic-pituitary-adrenal axis functioning in Huntington's disease and its association with depressive symptoms and suicidality.

Journal of neuroendocrinology - 1 Mar 2015

Hubers A A M, van der Mast R C, Pereira A M, Roos R A C, Veen L J, Cobbaert C M, van Duijn E, Giltay E J

Abstract excerpt

Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in Huntington's disease (HD). In non-HD populations, alterations in HPA axis activity have been associated with depression and suicidality. The present study aims to compare HPA axis activity between HD mutation carriers and controls, and examine its association with depressive symptoms and suicidality. To this end, salivary cortisol...

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Identifiers

PMID: 25565388
DOI: 10.1111/jne.12255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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